Research in the Bakel Lab focuses on applying genomics and transcriptomics technologies to fundamental questions in infectious disease biology and developmental genomics. We study host–pathogen interactions, viral and bacterial evolution, and molecular mechanisms that shape transmission and immune responses, while also investigating gene-regulatory programs underlying craniofacial and mandibular development. The lab is located in the Hess Center for Science and Medicine and is part of the Department of Genetics and Genomic Sciences and the Institute for Genomics and Multiscale Biology at the Icahn School of Medicine at Mount Sinai.
About the Lab
Our Team
The Bakel Lab brings together experimental scientists, clinicians, and computational researchers working at the intersection of genomics, infectious disease, and developmental biology. Our team combines bench-based molecular biology, next-generation sequencing, and clinical microbiology with large-scale bioinformatics, data science, and statistical modeling. Across projects ranging from influenza and SARS-CoV-2 surveillance to hospital-acquired infections and craniofacial development, we integrate laboratory experiments with real-time genomic analysis to understand pathogen evolution, host responses, and mechanisms of disease. This multidisciplinary environment allows us to translate complex biological questions into scalable computational workflows while maintaining strong experimental foundations.
Meet the Principal Investigator
Harm van Bakel, PhD
Associate Professor • Icahn School of Medicine at Mount Sinai
Harm van Bakel, PhD, is a genomicist and computational biologist with over two decades of experience applying genomics, transcriptomics, and bioinformatics to study host–pathogen interactions, infectious disease transmission, immune responses, and human development. The overarching goal of his research is to understand how genomic variation and gene regulation shape pathogen evolution, disease outcomes, and host biology, and to translate these insights into improved public health surveillance and clinical decision-making.
Contact
We’re located at the Hess Center for Science and Medicine on the Mount Sinai campus in New York City.